何春江 博士、教授、博导
che@whu.edu.cn；che@mail.hzau.edu.cn
教育经历：
1999.9-2003.6 武汉大学生命科学学院 生物技术 学士
2003.9-2008.6 武汉大学生命科学学院 细胞生物学 博士
工作经历与任职：
2009.2-2012.4 芝加哥大学医学院血液与肿瘤部 博士后
2012.5-2013.12 斯坦福大学医学院心血管研究所 博士后
2014.1-2020.9 武汉大学基础医学院 副教授
2020.10至今 华中农业大学生物医学与健康学院 教授
研究方向：
1. 研究RNA加工代谢和疾病的关联，开发可能的治疗策略。2. 研究影响造血健康和造血稳态的分子和细胞调控网络，开发新的干预途径
ORCID: https://orcid.org/0000-0002-4868-331x
代表论文（通讯*，一作#）：
1. Zhuo C#, Dong X#, Zhao X#, Wu W#, Zhou H, Feng J, Liu L, Feng M, He C*, Hou Y*. Single-cell sequencing reveals the expansion and diversity of T cell subsets in bone marrow microenvironment of chronic myeloid leukemia. Genes & Diseases. 2025.
2. Yao L#, Zhang X#, Li X#, Xu J#, Yang S, Li F, Chen W, Shan Y, Ren L, Zhuo C, Liang S, Chen L, Yin W, Liu H, Liu L, Feng M, Chen K*, Chen S*, He C*. circAFF2 promote the development of AML by binding to PML mRNA. Oncogene. 2025 Feb 10.
3. Chen W#, Chen X#, Yao L#, Feng J, Li F, Shan Y, Ren L, Zhuo C, Feng M, Zhong S*, He C*. A global view of altered ligand-receptor interactions in bone marrow aging based on single-cell sequencing. Computational and Structural Biotechnology Journal. 2024 Jun.
4. Dong X#, Chen K#, Chen W#, Wang J, Chang L, Deng J, Wei L, Han L*, Huang C*, He C*. circRIP: an accurate tool for identifying circRNA-RBP interactions. Briefings in Bioinformatics. 2022 Jun 1:bbac186.
5. Li J#, Chen K#, Dong X#, Xu Y, Sun Q, Wang H, Chen Z, Liu C, Liu R, Yang Z, Mei X, Zhang R, Chang L, Tian Z, Chen J, Liang K*, He C*, Luo M*. YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation. Cell Proliferation. 2022 Jan;55(1):e13157.
6. Feng J#, Chen W#, Dong X#, Wang J, Mei X, Deng J, Yang S, Zhuo C, Huang X, Shao L, Zhang R, Guo J, Ma R, Liu J, Li F, Wu Y*, Han L*, He C*. CSCD 2.0: An integrated interactional database of cancer-specific circular RNA. Nucleic Acids Research. 2021 Sep 22:gkab830.
7. Liu X#, Chen W#, Fang Y#, Yang S, Chang L, Chen X, Ye H, Tang X, Zhong S, Zhang W, Dong Z*, Han L*, He C*. ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissues. Briefings in Bioinformatics. 2021 Jul 13:bbab274.
8. Shao L#, Jiang G#, Yang X, Zeng M, Cheng J, Kong S, Dong X, Chen T, Han S, Yin J, Liu W, He X, He C*, Peng B*. Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy. FASEB J. 2021 Feb.
9. Xu X#, Zhang J#, Tian Y#, Gao Y#, Dong X, Chen W, Yuan X, Yin W, Xu J, Chen K*, He C*, Wei L*. CircRNA inhibits DNA damage repair by interacting with host gene. Molecular Cancer. 2020 Aug 24;19(1):128. doi: 10.1186/s12943-020-01246-x.
10. Xiao S#, Cao S#, Huang Q#, Xia L#, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W, Li Y, Liu S, Zhu H, Tan K, Luo Q, Zhong M*, He C*, Xia L*. The RNA N(6)-methyladenosine modification landscape of human fetal tissues. Nature Cell Biology. 2019 Apr 29. doi: 10.1038/s41556-019-0315-4
11. Feng J*#, Chen K#, Dong X#, Xu X, Jin Y, Zhang X, Chen W, Han Y, Shao L, Gao Y, He C*. Genome-wide identification of cancer-specific alternative splicing in circRNA. Molecular Cancer. 2019 Mar 8; 18(1):35. doi: 10.1186/s12943-019-0996-0.
12. Feng J#, Xiang Y#, Xia S#, Liu H, Wang J, Ozguc F, Lei L, Kong R, Diao L, He C*, Han L*. CircView: a visualization and exploration tool for circular RNAs. Briefings in Bioinformatics. 2018 Nov 27. doi: 10.1093/bib/bbx070.
13. Lei L#, Xia S#, Liu D#, Li X#, Feng J, Zhu Y, Hu J, Xia L, Guo L, Chen F, Cheng H, Chen K, Hu H, Chen X, Li F, Zhong S, Mittal N, Yang G, Qian Z, Han L*, He C*. Genome-wide characterization of lncRNAs in acute myeloid leukemia. Briefings in Bioinformatics. 2018 Jun 20. doi: 10.1093/bib/bbx007.
14. Xia S#, Feng J#, Chen K#, Ma Y, Gong J, Cai F, Jin Y, Gao Y, Xia L, Chang H, Wei L, Han L*, He C*. CSCD: A database for cancer-specific circular RNAs. Nucleic Acids Research. 2018 Jan 4. doi: 10.1093/nar/gkx863. ESI高被引
15. Xia S#, Feng J#, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L*, He C*. Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Briefings in Bioinformatics. 2017 Nov 1. doi: 10.1093/bib/bbw081. ESI高被引
16. He C*#, Hu H#, Wilson KD#, Wu H, Feng J, Xia S, Churko J, Qu K, Chang HY, Wu JC*. Systematic Characterization of Long Non-Coding RNAs Reveals the Contrasting Coordination of Cis- and Trans- Molecular Regulation in Human Fetal and Adult Heart. Circulation Cardiovascular Genetics. 2016 Apr. pii: CIRCGENETICS.115.001264.
17. Li Z#, Herold T#, He C#, Valk PJ, Chen P, Jurinovic V, Mansmann U, Radmacher MD, Maharry KS, Sun M, Yang X, Huang H, Jiang X, Sauerland MC, Büchner T, Hiddemann W, Elkahloun A, Neilly MB, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, Döhner K, Bullinger L, Liu PP, Delwel R, Marcucci G, Lowenberg B, Bloomfield CD, Rowley JD, Bohlander SK, Chen J*. Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study. Journal of Clinical Oncology. 2013 Mar 20;31(9):1172-81. doi: 10.1200/JCO.2012.44.3184.
18. He C#, Li Z#, Chen P#, Huang H, Hurst LD*, Chen J*. Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution. Nucleic Acids Research. 2012 May;40(9):4002-12. doi: 10.1093/nar/gkr1312.
19. Mi S#, Li Z#, Chen P#, He C#, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD*, Chen J*. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3710-5. doi: 10.1073/pnas.0914900107.
20. He C#, Zhou F, Zuo Z, Cheng H*, Zhou R*. A global view of cancer-specific transcript variants by subtractive transcriptome-wide analysis. PLoS One. 2009;4(3):e4732. doi: 10.1371/journal.pone.0004732.
21. He C#, Zuo Z, Chen H, Zhang L, Zhou F, Cheng H*, Zhou R*. Genome-wide detection of testis- and testicular cancer-specific alternative splicing. Carcinogenesis. 2007 Dec;28(12):2484-90.
研究资助：
1.国家自然科学面上项目 增强子circ-TRGC1调节启动子近侧暂停释放促进AML发生发展的机制研究 2022.1- 2025.12 主持
2.国家自然科学面上项目 circ-AFF2调控PRC2复合物介导的AML发生发展机制研究 2019.1- 2022.12 主持
3.国家自然科学青年基金 LncRNA-LINC01268通过激活HDAC2促进急性髓性白血病增殖的分子机制研究 2016.1-2018.12 主持
4.湖北省自然科学青年基金 基于生物信息学的急性髓性白血病lncRNA与mRNA作用网络的建立与验证 2015.1-2016.12 主持
5.中央高校自主科技创新基金项目 circRNA诱导AML细胞衰老的机制 2022.01-2024.12 主持
6.中央高校自主科研交叉项目 癌症特异环状RNA剪切数据库的构建 2018.1.-2019.12 主持
7.华中农业大学高层次人才启动经费 2020-2025 主持
学术兼职及获奖：
湖北省生理学会理事
武汉大学珞珈青年学者（2014）
武汉大学朱裕璧医学奖（2014）
湖北省人才计划（2016）
湖北省自然科学技术进步奖二等奖 （2021）
承担课程：
本科生：医学遗传学、病理生理学、基础医学导论
研究生招生：
实验室招收分子生物学、细胞生物学、生物信息学等方向的博士和硕士研究生
