张强 博士、副教授、博士生导师
中共党员,农业微生物资源发掘与利用全国重点实验室固定人员,湖北江夏实验室兼职研究员。聚焦动物流感、猪链球菌等重要人兽共患病以及非洲猪瘟等重大动物传染病,结合肠道微生物学、纳米生物学、药物化学等多个领域,长期致力于新型疫病防控技术的理论与应用研究。以第一或通讯作者(含共同)在Genome Biology、ACS Nano、Advanced Science、Gut Microbes等期刊共发表SCI论文20余篇,其中,中科院SCI分区1区11篇,入选微生物学领域高被引论文1篇;授权国家发明专利9件,国际发明专利2件;参与编写著作3部;主持国家自然科学基金项目2项、湖北省杰青项目1项、博士后科学基金1项,参与国家及省部级项目8项;获得湖北省科技成果推广一等奖1项(排名7/20)。担任Frontiers in Immunology客座副主编,npj Vaccines、Infection, Genetics and Evolution等杂志审稿人。
教育经历
2005.9-2009.6 山东农业大学,动物医学,学士
2009.9-2015.6 华中农业大学,预防兽医学,博士,导师:金梅林教授
工作经历
2015.7-2020.9 华中农业大学,生命科学技术学院,博士后,合作导师:金梅林教授/张忠明教授
2020.9至今 华中农业大学,动物科学技术学院、动物医学院/生物医学与健康学院,副教授
研究方向
1) 重要人兽共患病和重大动物传染病感染与抗感染机制研究
2) 新型检测技术和防控制剂开发
代表论文
1) Zhang Q, Hu J, Feng J, Hu X, Wang T, Gong W, Huang K, Guo Y, Zou Z, Lin X, Zhou R, Yuan Y, Zhang A, Wei H, Cao G, Liu C*, Chen L*, Jin M*, Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection. Genome Biol. 2020, 21(1):99. (独立一作,IF: 12.3)
2) Hu X, Sun X, Zhao Y, Iv C, Sun X, Jin M*, Zhang Q*. GlcNac produced by the gut microbiome enhances host influenza resistance by modulating NK cells. Gut Microbes. 2023 Dec;15(2):2271620. (主通讯,IF: 12.2)
3) Liu X, Yang C, Lin X, Sun X, Chen H, Zhang Q*, Jin M*. Phosphorylation of S-S-S Motif in Nuclear Export Protein (NEP) Plays a Critical Role in Viral Ribonucleoprotein (vRNP) Nuclear Export of Influenza A and B Viruses. Advanced Science. 2025;12(2):e2309477. (共同通讯,IF: 14.3)
4) Li B#, Zhao Y#, Wu X, Wu H, Tang W, Yu X, Mou J, Tan W, Jin M*, Li W*, Zhang Q*, and Liu M*. Abiotic Synthetic Antibody Inhibitor with Broad-Spectrum Neutralization and Antiviral Efficacy against Escaping SARS-CoV‑2 Variants. ACS Nano. 2023;17(7):7017-7034. (共同通讯,IF: 17.1)
5) Li R#., Zhao Y#, Fan H, Zhou H., Yin S, Zhang Q*, Jin M*, Liu G*, Huang L*, Metasurface-Driven and Nanomaterial-Coupled Plasmonic Biosensor for the Rapid and Quantitative Clinical Identification of Neutralizing Antibodies against SARS-CoV-2 Variants. Adv. Funct. Mater. 2023, 2306145. (共同通讯,IF: 19.0)
6) Zhang Q#, Zhang H#, Gao J#, Huang K, Yang Y, Hui X, He X, Li C, Gong W, Zhang Y, Zhao Y, Peng C, Gao X, Chen H, Zou Z*, Shi Z*, Jin M*. A serological survey of SARS-CoV-2 in cat in Wuhan. Emerg Microbes Infect. 2020, 9(1):2013-2019. (共一排一,IF: 13.2,高被引)
7) Li R#, Zhao Y#, Fan H#, Chen M, Hu W, Zhang Q*, Jin M*, Liu GL*, Huang L*. Versatile nanorobot hand biosensor for specific capture and ultrasensitive quantification of viral nanoparticles. Mater Today Bio. 2022;16:100444. (共同通讯,IF: 8.2)
8) Zhong ZJ, Hu XT, Cheng LP*, Zhang XY, Zhang Q*, Zhang J. Discovery of novel thiophene derivatives as potent neuraminidase inhibitors. Eur J Med Chem. 2021, 225:113762. (共同通讯,IF: 6.514)
9) Zhao Y#, Li R#, Lv C, Zhang Y, Zhou H, Xia X, Yu S, Wang Y, Huang L*, Zhang Q*, Liu GL*, Jin M*. One-Step Rapid and Sensitive ASFV p30 Antibody Detection via Nanoplasmonic Biosensors. Microbiol Spectr. 2022: e0234322. (共同通讯,IF:3.7)
10) Hu X, Zhao Y, Yang Y, Gong W, Sun X, Yang L, Zhang Q*, Jin M*. Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection. Front Microbiol. 2021, 11:586476. (共同通讯,IF:5.64)
11) Zhao Y#, Yang Y#, Gao J, Huang K, Hu C, Hui X, He X, Li C, Gong W, Lv C, Zhang Y, Chen H, Zou Z, Zhang Q*, Jin M*. A serological survey of severe acute respiratory syndrome coronavirus 2 in wuhan. Transbound Emerg Dis. 2021. doi: 10.1111/tbed.14024. (共同通讯,IF:5.005)
12) Hui X, Xu Z, Cao L, Liu L, Lin X, Yang Y, Sun X, Zhang Q*, Jin M*. HP0487 contributes to the virulence of Streptococcus suis serotype 2 by mediating bacterial adhesion and anti-phagocytosis to neutrophils. Vet Microbiol. 2021, 260:109164. (共同通讯,IF:3.293)
13) Wu C, Lv C, Zhao Y, Zhu W, Liu L, Wang T, Kang C, Yang Y, Sun X, Zhang Q*, Jin M*. Characterization of Erysipelothrix rhusiopathiae Isolates from Diseased Pigs in 15 Chinese Provinces from 2012 to 2018. Microorganisms. 2021; 9(12):2615. (共同通讯,IF: 4.128)
14) Yang H#, Huang J#, Hu X, Hu M, Zhang Q*, Jin M*. Comparative Genome Analysis of Streptococcus suis Serotype 9 Isolates from China, The Netherland, and the U.K. Life. 2021; 11(12):1324. (共同通讯,IF: 3.817)
15) Lv C#, Zhao Y#, Jiang L, Zhao L, Wu C, Hui X, Hu X, Shao Z, Xia X, Sun X, Zhang Q*, Jin M*. Development of a Dual ELISA for the Detection of CD2v-Unexpressed Lower-Virulence Mutational ASFV. Life. 2021; 11(11):1214. (共同通讯,IF: 3.817)
16) Yang Y, Lv C, Fan J, Zhao Y, Jiang L, Sun X, Zhang Q*, Jin M*. Development of a chemiluminescence immunoassay to accurately detect African swine fever virus antibodies in serum. J Virol Methods. 2021, 298:114269. (共同通讯,IF:2.014)
17) Zhang Q#, Huang J#, Yu J, Xu Z, Liu L, Song Y, Sun X, Zhang A* and Jin M*, HP1330 Contributes to Streptococcus suis Virulence by Inducing TLR2- and ERK1/2-Dependent Pro-inflammatory Responses and Influencing In Vivo S. suis Loads, Front Immunol. 2017, 8:869. (共一排一,IF:7.561)
18) Huang K#, Zhang Q#, Song Y, Zhang Z, Zhang A, Xiao J, Jin M*, Characterization of Spectinomycin Resistancein Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism, Antimicrob Agents Chemother. 2016, 7.25, (60): 6390~6392. (共同一作,IF:5.191)
19) Zhang Q#, Yang Y#, Yan S, Liu J, Xu Z, Yu J, Song Y, Zhang A, Jin M*, A novel pro-inflammatory protein of Streptococcus suis 2 induces the Toll-like receptor 2-dependent expression of pro-inflammatory cytokines in RAW 264.7 macrophages via activation of ERK1/2 pathway, Front Microbiol. 2015, 6: 178. (共一排一,IF:5.64)
20) Zhang Q, Liu J, Yan S, Yang Y, Zhang A, Jin M*. Fluoroquinolone-resistant Haemophilus parasuis isolates exhibit more putative virulence factors than their susceptible counterparts. J Clin Microbiol. 2013, 51(9):3130-1. (独立一作,IF:5.948)
21) Zhang Q, Zhou M, Song D, Zhao J, Zhang A, Jin M*. Molecular characterisation of resistance to fluoroquinolones in Haemophilus parasuis isolated from China. Int J Antimicrob Agents. 2013 Jul;42(1):87-9. (独立一作,IF:5.283)
22) Zhou M#, Zhang Q#, Zhao J, Jin M*. Haemophilus parasuis encodes two functional cytolethal distending toxins: CdtC contains an atypical cholesterol recognition/interaction region. PLoS One. 2012,7(3):e32580. (共同一作,IF:3.24)
授权专利
1) Meilin Jin; Qiang Zhang; Xiaotong Hu; Li Yang; Ting Wang; Xiaomei Sun; Chao Kang; Ming Zhong,Application of valine in preparing medicine for treating or preventing avian influenza virus infection, 2023-08-08,国际发明专利(美国), 申请号:US202117146413, 专利号:US11717503B2
2) Meilin Jin; Qiang Zhang; Xiaotong Hu; Li Yang; Jin Hu; Ting Wang; Xiaomei Sun; Zhong Zou; Wenxiao Gong; Xian Lin. Bifidobacterium animalis and application of compound bacterium preparation prepared from bifidobacterium animalis in preparing medicine for treating or preventing avian influenza virus infection, 2023-10-17, 国际发明专利(美国), 申请号:US202117141104,专利号:US 11786566B2
3) 金梅林,张强,胡晓通,杨丽,王婷,孙小美,康超,钟鸣,缬氨酸在制备治疗或预防禽流感病毒感染的药物中的应用,2020-12-22,中国,ZL202010048679.7
4) 金梅林,张强,胡晓通,杨丽,胡进,王婷,孙小美,邹忠,龚文孝,林显,动物双歧杆菌及其制备的复合菌制剂在制备治疗或预防禽流感病毒感染的药物中的应用,2020-12-01,中国,ZL202010031196.6
5) 金梅林,胡晓通,张强,杨丽,王婷,孙小美,康超,钟鸣,嗜黏蛋白阿克曼氏菌在制备治疗或预防禽流感病毒感染的微生态制剂中的应用,2021-05-14, 中国, ZL202010047686.5
6) 金梅林,杨永,张强,赵亚,孙小美,吕长杰,杨丽,一种非洲猪瘟病毒截短蛋白及其在制备ELISA检测试剂盒中的应用,2021-06-29,中国,ZL202010700335.X
7) 金梅林,杨永,张强,赵亚,孙小美,吕长杰,杨丽,一种非洲猪瘟病毒截短蛋白p54制备的单克隆抗体及其应用,2021-08-03,中国,ZL202010698954.X
8) 刘名茗,李冰雪,赵亚,张强,李炜,一种抗SARS-CoV-2病毒的人工模拟抗体及其应用,2023-04-07,中国,ZL202210939738.9
9) 金梅林,赵建平,周明光,宋岱松,张强,张安定,石建,康超,徐高原,陈焕春,表达副猪嗜血杆菌表面抗原的猪霍乱沙门氏菌减毒疫苗,2015.10.28,中国,ZL201310039113.8
10) 金梅林,赵建平,周明光,宋岱松,张强,张安定,石建,康超,徐高原,陈焕春,一种副猪嗜血杆菌减毒沙门氏菌苗,2015.10.28,中国,ZL201310039080.7
11) 金梅林,赵建平,周明光,宋岱松,张强,张安定,石建,康超,徐高原,陈焕春,一种副猪嗜血杆菌-猪霍乱沙门氏菌二联基因工程苗,2015.10.28,中国,ZL201310040712.1
基金项目
1) 国家自然科学基金面上项目,32172891,流感病毒感染诱导肠道代谢分子GlcNAc合成及其抗流感作用机制的研究,2022/01-2025/12,58万元,在研,主持
2) 国家自然科学基金青年科学基金项目,31702253,猪链球菌表面蛋白ZnMc诱导过度炎症反应的分子机制研究,2018/1-2020/12,26万元,已结题,主持
3) 中国博士后科学基金面上项目一等资助, 2015M580654,猪链球菌2型抑炎蛋白HP1914作用机制的研究,2015/11-2017/11,8万元,已结题,主持
4) 国家重点研发计划,2016YFD0500801,家禽重大疫病诊断新技术研究,2016/7-2020/12,693万元(本人可支配金额70万元),已结题,骨干
5) 湖北省重点研发计划,2021ACB004,变异新冠病毒预警及风险评估体系建设,2021/01-2021/12,400万元(本人可支配金额20万元),在研,骨干
6) 国家重点研发计划,2020YFC0845800,新型冠状病毒感染不同进程与宿主的相互作用研究,400万元(本人可支配金额20万元),2020/3-2021/6, 已结题,骨干
7) 湖北省重大专项,2020ABA016,主要动植物品种选育及生物制品研发, 2020/11-2023/12,630万元(本人可支配金额20万元),在研,骨干
8) 湖北省技术创新专项重大项目,2019ABA089,非洲猪瘟防控关键技术研究与示范,500万元(本人可支配金额10万元),2019/1-2021/12,已结题,骨干
9) 武汉市科技重大专项,2023020302020573,非洲猪瘟新型疫苗创制,2000万(本人可支配金额48万元),2023/6-2026/6,在研,骨干
10) 新进教师科研启动专项,2662021SYQD002,流感病毒感染诱导肠道代谢分子GlcNAc的合成及其抗流感作用机制的研究,2021/01-2023/12,20万,在研,主持
获得奖项
1) 金梅林,康超,谭臣,汤细彪,张安定,王湘如,张强,徐高原,吴斌,张锦军,周明光,陈关平,魏燕鸣,钟鸣,贝为成,钱平,陈幕琳,孙小美,陈波,尹争艳。猪链球菌病高效安全防控技术集成与推广应用,湖北省成果推广奖一等奖,2018.12。