石秀娟博士，副教授
教育经历：
2010/09-2015/06，苏州大学，高分子化学与物理，博士
2006/09-2010/06，武汉理工大学，高分子材料与工程，本科
工作经历与任职：
2023/06-至今，华中农业大学，生物医学与健康学院，副教授
2022/07-2023/05，华中农业大学，生物医学与健康学院，科研助理
2015/11-2020/06，香港科技大学，化学与生物工程系，博士后
研究方向：
利用新型聚集诱导发光分子探针、免疫佐剂或光催化剂来研究免疫组织和肿瘤微环境中从小分子、大分子到细胞层次上的免疫调节方法和作用机制。
1. 营养物以及代谢物在免疫组织和肿瘤微环境中的作用过程研究。利用聚集诱导发光分子探针标记营养物及代谢物以研究其在组织、类器官、活体动物层次上的时空分布和生物过程。
2. 研发新型佐剂通过激活特定免疫细胞以辅助增强肿瘤疫苗的功效。设计和合成新型聚集诱导发光材料或者聚合物佐剂，筛选出有效的免疫佐剂，并且研究其作用机制。
3. 研发光催化邻近生物标记的工具，以研究肿瘤微环境中免疫细胞之间或生物分子之间的互作关系。
代表性论文：
1. Xiujuan Shi#, Jun Zhang#, Junkai Liu, Xueqian Zhao, Haoran Wang, Peifa Wei, Xiaodong Zhang, Xin-Long Ni, Herman H.-Y. Sung, Ian D. Williams, Wai Kit Ng, Kam Sing Wong, Jacky W. Y. Lam, Lin Wang*, Honglin Jin*, Ben Zhong Tang*. Hierarchical Supramolecular Self-assembly: Fabrication and Visualization of Multiblock Microstructures. Angew. Chem. Int. Ed. 2022, e202211298.
2. Liuliang Yuan#, Xiujuan Shi#, Ben Zhong Tang, Wen-Xiong Wang*, Real-time in vitro monitoring of the subcellular toxicity of inorganic Hg and methylmercury in zebrafish cells, Aquatic Toxicology 2021, 236, 105859.
3. Xiujuan Shi#, Simon H. P. Sung#, Joe H. C. Chau, Ying Li,* Zhiyang Liu, Ryan T. K. Kwok,* Junkai Liu, Peihong Xiao, Jiangjiang Zhang, Bin Liu, Jacky W. Y. Lam, and Ben Zhong Tang*. Killing G(+) or G(−) Bacteria? The Important Role of Molecular Charge in AIE-Active Photosensitizers. Small Methods, 2020, 4(7): 2000046.
4. Xiaodong Zhang#, Xiujuan Shi#, Shaoyuan Su, Guilin Zhou, Xin-Long Ni*. Tunable fluorescent pseudorotaxane from axle-length-dependent cucurbit[7]uril complexation. Dyes and Pigments, 2020, 172: 107785.
5. Xiujuan Shi#, Neng Yan#, Guangle Niu, Simon H. P. Sung, Zhiyang Liu, Junkai Liu, Ryan T. K. Kwok,* Jacky W. Y. Lam, Wen-Xiong Wang*, Herman H.-Y. Sung, Ian D. Williams and Ben Zhong Tang*. In vivo monitoring of tissue regeneration using a ratiometric lysosomal AIE probe. Chemical Science, 2020, 11(12): 3152-3163.
6. Xiujuan Shi#, Simon H. P. Sung#, Michelle M. S. Lee, Ryan T. K. Kwok,* Herman H. Y. Sung, Haixiang Liu, Jacky W. Y. Lam, Ian D. Williams, Bin Liu* and Ben Zhong Tang*. A lipophilic AIEgen for lipid droplet imaging and evaluation of the efficacy of HIF-1 targeting drugs. Journal of Materials Chemistry B, 2020, 8(7): 1516-1523.
7. Xiujuan Shi, Xiaodong Zhang, Xin-Long Ni, Haoke Zhang, Peifa Wei, Junkai Liu, Hao Xing, Hui-Qing Peng, Jacky W. Y. Lam, Pengfei Zhang, Zaiyu Wang, Hongxia Hao,* and Ben Zhong Tang*. Supramolecular Polymerization with Dynamic Self-Sorting Sequence Control. Macromolecules, 2019, 52(22): 8814-8825.
8. Xiujuan Shi#, Chris Y. Y. Yu#, Huifang Su, Ryan T. K. Kwok, Meijuan Jiang, Zikai He, Jacky W. Y. Lam and Ben Zhong Tang*. A red-emissive antibody-AIEgen conjugate for turn-on and wash-free imaging of specific cancer cells. Chemical Science, 2017, 8(10): 7014-7024.
9. Zhonglin Lyu#, Xiujuan Shi#, Jiehua Lei, Yuqi Yuan, Lin Yuan, Qian Yu* and Hong Chen*. Promoting neural differentiation of embryonic stem cells using beta-cyclodextrin sulfonate. Journal of Materials Chemistry B, 2017, 5(10): 1896-1900.
10. Wenjun Zhan#, Xiujuan Shi#, Qian Yu*, Zhonglin Lyu, Limin Cao, Hui Du, Qi Liu, Xin Wang, Gaojian Chen, Dan Li, John L. Brash, and Hong Chen*. Bioinspired Blood Compatible Surface Having Combined Fibrinolytic and Vascular Endothelium-Like Properties via a Sequential Coimmobilization Strategy. Advanced Functional Materials, 2015, 25(32): 5206-5213.
11. Xiujuan Shi#, Wenjun Zhan#, Gaojian Chen,* Qian Yu, Qi Liu, Hui Du, Limin Cao, Xiaoli Liu, Lin Yuan, and Hong Chen*. Regulation of Protein Binding Capability of Surfaces via Host-Guest Interactions: Effects of Localized and Average Ligand Density. Langmuir, 2015, 31(22): 6172-8.
12. Xiujuan Shi, Gaojian Chen*, Lin Yuan, Zengchao Tang, Wei Liu, Qiang Zhang, David M. Haddleton and Hong Chen*. Integrating a thermoresponsive copolymer with host–guest interactions for fabricating molecular recognition surfaces. Materials Horizons, 2014, 1(5): 540-545.
13. Xiu-Juan Shi, Gao-Jian Chen,* Yan-Wei Wang, Lin Yuan, Qiang Zhang, David M. Haddleton, and Hong Chen*. Control the wettability of poly(n-isopropylacrylamide-co-1-adamantan-1-ylmethyl acrylate) modified surfaces: the more Ada, the bigger impact? Langmuir, 2013, 29(46): 14188-95.
14. Xiujuan Shi, Yanyun Wang, Dan Li, Lin Yuan,* Feng Zhou, Yanwei Wang, Bo Song, Zhaoqiang Wu, Hong Chen,* and John L. Brash. Cell adhesion on a POEGMA-modified topographical surface. Langmuir, 2012, 28(49): 17011-8.
15. Shi, XiuJuan; Li, Dan; Xie, Jing; Wang, Shawn; Wu, ZhaoQiang; Chen, Hong*. Spectroscopic investigation of the interactions between gold nanoparticles and bovine serum albumin. Chinese Science Bulletin, 2012, 57(10): 1109-1115. (2015年英文版改名为Science Bulletin)
基金项目：
1. AIE材料在生物偶联、生物成像和癌症诊疗方面的研究（深圳市科技创新委员会，深圳自由探索P1720，2018/03-2020/09）：主持，通过验收。
2. Institute of Molecular Functional Materials (the University Grants Committee of Hong Kong, 香港，2014/01-2018/12)：参与。
3. Aggregation-Induced Emission (AIE): Development of New AIE Systems and Exploration of Their Biomedical Applications (the Research Grants Council of Hong Kong, 香港，2018/03-2021/02)：参与。
4. Hong Kong Branch of National Engineering Research Center for Tissue Restoration & Reconstruction (the Innovation and Technology Commission, 香港，2015/10-2021/03)：参与。
授权专利：
1. 用于癌细胞成像的聚集诱导发光体：唐本忠，石秀娟，余义勇，郭子健，赵征，张鹏飞，苏会芳。专利号ZL201780037847.9
2. 一种序列可控的超分子聚合物及其制备方法和应用：唐本忠，石秀娟，彭慧晴，林荣业。专利号ZL201910419269.6
3. 具有聚集诱导发光性质的比率型溶酶体pH探针及应用：唐本忠，石秀娟，牛广乐，郭子健。专利号ZL201911101156.8
4. 一种靶向脂滴的AIEgen、制备方法及应用，技术发明：唐本忠，石秀娟，郭子健，宋海鹏。专利号ZL201911146263.2
学术兼职：
担任Biomaterials、Polym. Chem.、J. Mater. Chem. B、Nanoscale等学术期刊的审稿人，作为书本Handbook of Aggregation-Induced Emission, Volume 3: Emerging Applications（Publisher: Wiley, 2021）的评审专家。
联系方式（邮箱）
xiujuanshi@mail.hzau.edu.cn
