李锦铨 博士、教授、博士生导师、国家优青获得者
教育经历：
2005-2009华中农业大学/生物技术/学士
2009-2013华中农业大学/预防兽医/博士，导师：陈焕春院士
2011-2013 Montana state University/感染与免疫/中美联培博士
工作经历与任职：
2021-至今 华中农业大学 教授
2021-至今 上海噬菌体与耐药研究所 兼职PI
2020-至今 洛克菲勒大学 噬菌体与传染病客座研究员
2018-2020洛克菲勒大学 传染病博士后，合作导师：Vincent A. Fischetti教授
2013-2021华中农业大学 讲师、副教授
研究方向：
主要围绕“超级细菌”分子致病机制、噬菌体高效杀菌机制和功能性噬菌体开展研究工作，获批国家自然科学基金优秀青年科学基金、农业农村部农业科研杰出人才培养计划、湖北省杰出青年科学基金支持。
1.病原菌突破血脑屏障分子机制和跨宿主传播机制
2.人兽共患病原菌噬菌体资源库、合成噬菌体、治疗性噬菌体生产工艺
3.基于组学技术高通量筛选新型噬菌体裂解酶/噬菌肽
4.新功能噬菌体的发掘和机制研究（肿瘤微环境，治疗代谢性疾病）
代表论文：
1. Geng Zou Lijun He, Jing Rao, Zhiyong Song, Hu Du, Runze Li, Wenjing Wang, Yang Zhou, Lu Liang, Huanchun Chen, Jinquan Li*. Improving the safety and efficacy of phage therapy from the perspective of phage-mammal interactions. FEMS microbiology reviews. 2023 Jul 5;47(4): fuad042.
2. Xingxing Dong#, Yanjie Chao#, Yang Zhou, Rui Zhou, Wei Zhang, Vincent A. Fischetti, Xiaohong Wang, Ye Feng*, Jinquan Li*. The global emergence of a novel Streptococcus suis clade associated with human infections. EMBO Molecular Medicine, 2021, e13810.
3. Yufan Yang, Hu Du, Geng Zou, Zhiyong Song, Yang Zhou, Hao Li, Chen Tan, Huanchun Chen, Vincent A Fischetti, Jinquan Li*. Encapsulation and delivery of phage as a novel method for gut flora manipulation in situ: A review. Journal of Controlled Release, 2023,353: 634-649.
4. Zhiwei Li, Peixi Chang, Jiali Xu, Chen Tan, Xiaohong Wang, Weicheng Bei, Jinquan Li*. A Streptococcus suis Live Vaccine Suppresses Streptococcal Toxic Shock-Like Syndrome and Provides Sequence Type Independent Protection. The Journal of Infectious Diseases, 2019, 219(3): 448-458.
5. Chad W Euler, Assaf Raz, Anaise Hernandez, Anna Serrano, Siyue Xu, Martin Andersson, Geng Zou, Yue Zhang, Vincent A Fischetti, Jinquan Li*. PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens. Antimicrobial Agents and Chemotherapy, 2023,17;67(5): e0151922.
6. Yue Zhang, Geng Zou, Md Sharifull Islam, Kun Liu, Suqiang Xue, Zhiyong Song, Yingwang Ye, Yang Zhou, Yuanguo Shi, Shaozhong Wei, Rui Zhou, Huanchun Chen, Jinquan Li*. Combine thermal processing with polyvalent phage LPEK22 to prevent the Escherichia coli and Salmonella enterica contamination in food. Food Research International, 2022, 165:112454.
7. Lin Teng, Geng Zou, Yang Zhou, Jie Li, Zhiyong Song, Xingxing Dong, Zhengxin Ma, Zhijie Zheng, Huanchun Chen,Li Jinquan*.Phage controlling method against novel freshwater-derived Vibrio parahaemolyticus in ready-to-eat crayfish (Procambarus clarkii). Food Research International, 2022,162:111986.
8. Yu Jin, Ke Liu, Guangqiang Li, Chengfei Li, Zhidong Xiao, Chao Yuan*,Jinquan Li*. In situ reduction triggers the highly sensitive detection of pesticide by classic gold nanoparticle and quantum dots nanocomposite. Analytica Chimica Acta, 2021, 1172:338679
9.Yating Guo#, Jie Li#, Md.Sharifull Islam, Ting Yan, Yang Zhou, Lu Liang, Ian F.Connerton, Kai Deng, Jinquan Li*. Application of a novel phage vB_SalS-LPSTLL for biological control of Salmonella in foods. Food Research International, 2021, 147:110492
10.Siyue Xu, Edmondo Campisi*, Jinquan Li*, Vincent A. Fischetti. Decontamination of Escherichia coli O157:H7 on Fresh Romaine Lettuce Using a Novel Bacteriophage Lysin.International Journal of Food Microbiology, 2021, 341:109068
11.Sharifull Islam, Md, Xiangwei Yang, Chad W. Euler, Xueqing Han, Jiahui Liu, Isrfil Hossen, Md, Yang Zhou, Jinquan Li*. Application of a novel phage ZPAH7 for controlling multidrug-resistant Aeromonas hydrophila on lettuce and reducing biofilms. Food Control, 2021, 122 :107785
12.Md. Sharifull Islam, Yang Zhou, Lu Liang, Ishatur Nime, Ting Yan, Stephan P. Willias, Md. Zakaria Mia, Weicheng Bei, Ian F. Connerton, Vincent A. Fischetti,Jinquan Li*. Application of a Broad Range Lytic Phage LPST94 for Biological Control of Salmonella in Foods. Microorganisms, 2020, 8(2):247.
13.Ting Yan, Lu Liang, Ping Yin, Yang Zhou, Ashraf Mahdy Sharoba, Qun Lu, Xingxing Dong, Kun Liu, Ian F. Connerton, Jinquan Li*. Application of a Novel Phage LPSEYT for Biological Control of Salmonella in Foods. Microorganisms, 2020, 8(3):400.
14.Md. Sharifull Islam, Yang Zhou, Lu Liang, Ishatur Nime, Kun Liu, Ting Yan, Xiaohong Wang, Jinquan Li*. Application of a Phage Cocktail for Control of Salmonella in Foods and Reducing Biofilms. Viruses, 2019, 11(9): 841.
15.Feng Liu#,Jinquan Li#, Kang Yan, Huan Li, Chengfeng Sun, Shuo Zhang, Fangyan Yuan, Xiangru Wang, Chen Tan, Huanchun Chen, Weicheng Bei*, Binding of Fibronectin to SsPepO Facilitates the Development of Streptococcu suis Meningitis, The Journal of Infectious Diseases, 2018, 217(6):973-982.
16.Chenxi Huang, Safiullah M. Virk, Jianchun Shi, Yang Zhou, Stephan P. Willias, Mohamed K. Morsy, Hazem E. Abdelnabby, Jie Liu, Xiaohong Wang*, Jinquan Li*. Isolation, Characterization, and Application of Bacteriophage LPSE1 Against Salmonella enterica in Ready to Eat (RTE) Foods.Frontiers in Microbiology, 2018, 9:1046.
17.Liping Feng, Xiaona Niu, Wen Mei, Weitian Li, Yuan Liu, Stephan P. Willias, ChaoYuan, Weicheng Bei, Xiaohong Wang, Jinquan Li*. Immunogenicity and protective capacity of EF-Tu and FtsZ of Streptococcus suis serotype 2 against lethal infection. Vaccine, 2018, 36(19):2581-2588.
18.Ying Zhou, Ruonan Nie, Xiaoyue Liu, Jinghui Kong, Xiaohong Wang,Jinquan Li*. GntR is involved in the expression of virulence in strain Streptococcus suis P1/7.FEMS Microbiology Letters, 2018, 365(14).
19.Xingxing Dong, Xiaohong Wang, Xingchun Chen, Zhiyun Yan, Jing Cheng, Liangliang Gao, Yuan Liu, Jinquan Li*. Genetic Diversity and Virulence Potential of Staphylococcus aureus Isolated from Crayfish (Procambarus clarkii). Current Microbiology, 2017, 74(1):28-33.
20.Yang Zhou, Xingxing Dong, Zhiwei Li, Geng Zou, Li Lin, Xiaohong Wang, Huanchun Chen, Robin B. Gasser, Jinquan Li*. Predominance of Streptococcus suis ST1 and ST7 in human cases in China, and detection of a novel sequence type, ST658.Virulence, 2017, 8(6):1031-1035.
21.Xingxing Dong, Zhi Li, Xiaohong Wang, Min Zhou, Li Lin, Yang Zhou, Jinquan Li*. Characteristics of Vibrio parahaemolyticus isolates obtained from crayfish (Procambarus clarkii) in freshwater. International Journal of Food Microbiology, 2016:132-138.
22.魏 麟（本科生），朱方莉，周 洋，Khairy Morsy MOHAMED，袁 超，董星星，王小红，李锦铨*.噬菌体在检测食源性病原菌中的应用研究进展.食品科学, 2018，(1):314-322.
23.吕阳（本科生），尹平，Khairy Morsy MOHAMED，高磊，袁超，周洋，邱宁，邹璐瑶，李志，Abdelnabby HAZEM，王小红，李锦铨*.噬菌体在食品安全控制中的研究进展,食品科学, 2018,(15):240-246
24.郭浩然（本科生），许菁彦，周 洋，李子齐，邱熠鑫，魏 麟，董星星，李锦铨*.噬菌体分布的广泛性以及口服安全性，中国食品学报，2021,21(02):349-357.
基金项目：
1. 人兽共患病与公共卫生，国家自然科学基金优秀青年科学基金项目， 2024.01-2026.12，主持
2. 湖北省杰出青年科学基金，2023-2026，主持
3. 农业农村部农业科研杰出人才培养计划，2021.09-2022.09，主持
4. 高效裂解耐药大肠杆菌的非透膜剂依赖型噬菌体裂解酶作用机制研究，2021.1-2024.12，国家自然科学基金面上项目，主持
5. 噬菌体多糖解聚酶介导的肠炎沙门氏菌生物被膜消除机制，2018.1-2021.12，国家自然科学基金面上项目，主持
6.“十四五”国家重点研发计划“猪细菌性疫病新型疫苗创制”项目子课题, 2022.11-2025.12, 国家重点研发计划,主持
7. 猪链球菌2型内皮素转化酶的致病机制研究，2016.1-2018.12，国家自然科学基金青年科学基金项目，主持
8. 耐药梭菌噬菌体高效裂解酶的发掘和作用机制研究，2019.1-2020.12，湖北省科技创新专项（中美合作专项），主持
9. 湖北地区小龙虾中副溶血弧菌污染状况和污染机制研究，2015.1-2016.12，湖北省自然科学基金，主持
10. 重要食源性致病菌耐药机制及传播规律研究，2018.1-2021.12，国家重点研发计划，研究骨干
授权专利：
1.一种主效成分为噬菌体LPEE17和LPEK22的混合制剂及应用. CN110317793B.发明专利.2020.06.中国.1/4.
2.沙门氏菌噬菌体和噬菌体抗菌组合物及其应用. CN106497888B.发明专利. 2018.06.中国.1/8.
3.一种宽谱沙门氏菌噬菌体LPSTLL及应用.CN109825479B.发明专利.2019.02.中国.2/7.
4.一种猪链球菌2型10基因缺失株及应用. CN106085936B.发明专利.2019.02.中国.1/6.
5.一种区分猪链球菌爆发菌株和散发菌株的检测引物和应用.CN106868143B.发明专利.2018.10.中国.1/10.
6.一种猪链球菌2型五基因缺失株及应用.CN105316252B.发明专利.2018.08.中国.1/7.
7.一种鸡常见食源性细菌四重荧光PCR检测试剂盒及使用方法.CN103436626B.发明专利.2015.09.中国.8/9.
8.一种猪链球菌2型的SS2-LAMP检测试剂盒及应用.CN104404132B.发明专利.2016.02.中国.1/5.
9.一种高致病性嗜水气单胞菌及应用.CN105695372B.发明专利.2018.05.中国.2/7.
10.一种无抗生素标记的嗜水气单胞菌减毒菌及应用.CN105886429B.发明专利.2019.04.中国.2/7.
11.一种肠炎沙门氏菌噬菌体LPSE28及其在食品中的应用.CN108546685B.发明专利.2021.01.中国.1/9.
12.一种沙门氏菌噬菌体LPSE34及其在食品中的应用.CN108588037B.发明专利.2021.01.中国.1/9.
学术兼职：
《Frontiers in Microbiology》主题编辑，《食品科学》、《Virulence》、《Vaccine》、《Microbiology Spectrum》、《Infection and Immunity》、《International Journal of Food Microbiology》、《Frontiers in Cellular and Infection Microbiology》、《Microorganisms》和《Viruses-Basel》等SCI期刊审稿人
联系方式（邮箱）：
lijinquan2007@gmail.com ；lijinquan@mail.hzau.edu.cn
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