专任教师

金红林

访问次数:发布日期:2021-04-21

金红林 博士、教授、博导


教育经历:

2007/09-2012/06,华中科技大学,生物化学与分子生物学,博士

2005/09-2007/06,华中科技大学,生物化工,硕士

2001/09-2005/06,湖北工业大学,生物工程,本科


工作经历与任职:

2021/04-至今,华中农业大学,生物医学与健康学院,教授

2014/07-2021/04,华中科技大学,武汉协和医院肿瘤中心,讲师/副研究员/研究员

2012/04-2014/06,华中科技大学,武汉光电国家实验室,博士后

2008/05-2011/01,多伦多大学/安大略癌症研究院,Medical Biophysics,访问学者


研究方向:

肿瘤免疫治疗新技术、新靶点,以及相关免疫机制研究注重学科交叉融合和临床转化。

1、免疫细胞调控/重塑新靶点和新机制;

2、放射衍生物和肿瘤免疫治疗:通过研究经典的放射生物学效应,对放疗产物进行鉴定分析,一方面探索放疗免疫增效新机制,另一方面建立系列“间接放疗新技术”;

3、通过设计系列抗肿瘤载体平台策略,克服肿瘤免疫抑制性微环境,提高T细胞在肿瘤微环境中的活性,构建个体化肿瘤疫苗。


代表性论文:

1. Xiujuan Shi#, Jun Zhang#, Junkai Liu, Xueqian Zhao, Haoran Wang, Peifa Wei, Xiaodong Zhang, Xin-Long Ni, Herman H.-Y. Sung, Ian D. Williams, Wai Kit Ng, Kam Sing Wong, Jacky W. Y. Lam, Lin Wang*, Honglin Jin*, Ben Zhong Tang*. Hierarchical Supramolecular Self-assembly: Fabrication and Visualization of Multiblock Microstructures. Angew. Chem. Int. Ed. 2022, e202211298.

2. Zhiyun Liao#, Jing Huang#, Pui-Chi Lo, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. Self-adjuvanting Cancer Nanovaccines. Journal of Nanobiotechnology. 2022. 20 (1), 1-20.

3. Danyi Zai#, Jing Huang#, Yan Hu#, Chao Wan, Yajie Sun, Jingshu Meng, Huaduan Zi, Lisen Lu, Qianyuan He, Yu Hu, Honglin Jin*, Kunyu Yang*. Ionizing radiation-induced tumor cell-derived microparticles prevent lung metastasis by remodeling the pulmonary microenvironment. International Journal of Radiation Oncology Biology Physics. 2022. 114 (3), 502-515.

4. Yan Hu#, Yajie Sun#, Chao Wan, Xiaomeng Dai, Shuhui Wu, Pui-Chi Lo, Jing Huang, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research. Journal of Nanobiotechnology. 2022. 20(1), 189.  

5. Zhan Tuo#, Qianyuan He#, Zhanjie Zhang#, Haojie Liu, Jie Zhou, Yan Hu, Yajie Sun, Chao Wan, Zushun Xu, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. Irradiation conditioning of adjuvanted, autologous cancer cell membrane nanoparticle vaccines. Chemical Engineering Journal. 2022. 433: 134437.

6. Yuhan Zhou#, Ting Ye#, Chengzhi Ye#, Chao Wan, Siyue Yuan, Yushuai Liu, Tianyu Li, Fagang Jiang, Jonathan F. Lovell, Honglin Jin*, Jing Chen*. Secretions from hypochlorous acid-treated tumor cells delivered in a melittin hydrogel potentiate cancer immunotherapy. Bioactive Materials. 2022. 9, 541-553.

7. Chao Wan#, Yajie Sun#, Yan Hu#, Jing Huang#, Lisen Lu, Jingshu Meng, Yanan Gao, Huaduan Zi, Qianyuan He, Jonathan F. Lovell, Kunyu Yang*, Honglin Jin*. Radiated tumor cell secretions loaded peptide hydrogel for immunotherapy to advanced cancer. Nano Today. 2021. 41, 101323.

8. Yushuai Liu#, Yuanyuan Geng#, Beilei Yue, Pui-Chi Lo, Jing Huang*, Honglin Jin*. Injectable Hydrogel as A Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment. Frontiers in Immunology. 2021. 12, 832942.

9. Jingshu Meng#, Yan Li#, Chao Wan#, Yajie Sun, Xiaomeng Dai, Jing Huang, Yan Hu, Yanan Gao, Jonathan F. Lovell, Gang Wu, Honglin Jin*, Kunyu Yang*. Targeted senescence-like cancer-associated fibroblasts increases non-small cell lung cancer radiosensitivity and ameliorates radiation-induced pulmonary fibrosis. JCI Insight. 2021. 6(23): e146334.

10. Yajie Sun#, Yan Hu#, Chao Wan, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. Local biomaterials-assisted immunotherapy for effusions in the pleural and peritoneal cavities caused by malignancies. Biomaterials Science. 2021. 9, 6381-6390.

11. Lisen Lu#, Yajie Sun#, Chao Wan, Yan Hu, Pui-Chi Lo, Kunyu Yang*, Honglin Jin*. Role of intravital imaging in nanomedicine-assisted anti-cancer therapy. Current Opinion in Biotechnology. 2021. 69. 153-161.

12. Jie Zhou#, Chao Wan#, Jing Cheng, Hao Huang*, Jonathan F. Lovell, Honglin Jin*. Delivery strategies for melittin-based cancer therapy. ACS Applied Materials & Interfaces. 2021. 13, 15, 1715817173.

13. Yanan Gao#, You Qin#, Chao Wan, Yajie Sun, Jingshu Meng, Yan Hu, Jing Huang, Honglin Jin*, Kunyu Yang*. Small extracellular vesicles: a novel avenue for cancer management. Frontiers in Oncology. 2021. 11 : 441

14. Yajie Sun, Xiangru Feng, Chao Wan, Jonathan F. Lovell, Honglin Jin*, Jianxun Ding*. Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy. Asian Journal of Pharmaceutical Sciences. 2021. 6.12 : 129-132.

15. Chao Wan#, Yajie Sun#, Yu Tian#, Lisen Lu, Xiaomeng Dai, Jingshu Meng, Jing Huang, Qianyuan He, LingLing Zhang, Jonathan F. Lovell, Gang Wu, Honglin Jin*, Kunyu Yang*. Irradiated tumor cell-derived microparticles mediate tumor eradication via cell killing and immune reprogramming. Science Advances. 2020. 6 : eaay9789.

16. Xiaomeng Dai#, Lisen Lu#, Suke Deng, Jingshu Meng, Chao Wan, Jing Huang, Yajie Sun, Yan Hu, Bian Wu, Gang Wu, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. USP7 targeting modulates antitumor immune response by reprogramming tumor-associated macrophages in lung cancer. Theranostics. 2020. 10(20):9332-9347.

17. Xiaomeng Dai#, Jingshu Meng#, Suke Deng#, Lingling Zhang, Chao Wan, Lisen Lu, Jing Huang, Yan Hu, Zhanjie Zhang, Jonathan F. Lovell, Gang Wu, Kunyu Yang*, Honglin Jin*. Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel. Theranostics. 2020. 10(7): 3049-3063.  

18. Qianyuan He#, Zhanjie Zhang#, Haojie Liu, Zhan Tuo, Jie Zhou, Yan Hu, Yajie Sun, Chao WanZushun Xu, Jonathan F. Lovell, Desheng Hu*, Kunyu Yang*, Honglin Jin*. Relieving immunosuppression during long-term anti-angiogenesis therapy using photodynamic therapy and oxygen delivery. Nanoscale. 2020. 12, 14788-14800.

19. Boyang Sun#, Jing Huang#, Moustafa T. Mabrouk, Yumiao Zhang, Honglin Jin*, Jonathan F Lovell*. A surfactant-stripped cabazitaxel micelle formulation optimized with accelerated storage stability. Pharmaceutical Development and Technology. 2020. 25.10: 1281-1288.

20. Haojie Liu#, Yan Hu#, Yajie Sun#, Chao Wan, Zhanjie Zhang, Xiaomeng Dai, Zihan Lin, Qianyuan He, Zhe Yang, Piao Huang, Yuxuan Xiong, Jinguo Cao, Xu Chen, Qi Chen, Jonathan F. Lovell, Zushun Xu*, Honglin Jin* and Kunyu Yang*. Co-delivery of bee venom melittin and a photosensitizer with an organicinorganic hybrid nanocarrier for photodynamic therapy and immunotherapy. ACS Nano. 2019. 13(11), 12638-12652.

21. Dyego Miranda#, Chao Wan#, Hailey I Kilian, Moustafa T. Mabrouk, Yuhan Zhou, Honglin Jin*, Jonathan F Lovell*. Indocyanine green binds to DOTAP liposomes for enhanced optical properties and tumor photoablation. Biomater. Sci. 2019, 7, 3158-3164.  

22. Honglin Jin#, Chao Wan#, Zhenwei Zou#, Guifang Zhao, LingLing Zhang, Yuanyuan Geng, Tong Chen, Ai Huang, Fagang Jiang, Jue-Ping Feng, Jonathan F. Lovell, Jing Chen*, Gang Wu*, and Kunyu Yang*. Tumor Ablation and Therapeutic Immunity Induction by an Injectable Peptide Hydrogel. ACS Nano. 2018, 12 (4), 3295–3310.

23. Yanwu Chu, Feng Chen, Yun Tang, Tong Chen, Yunxin Yu, Honglin Jin*, Lianbo Guo*, Yongfeng Lu, and Xiaoyan Zeng. Diagnosis of nasopharyngeal carcinoma from serum samples using hyperspectral imaging combined with a chemometric method. Optics Express. 2018. 26 (22), 28661-28671.

24. Yanwu Chu#, Tong Chen#, Feng Chen, shisong Tang, Yun Tang, Honglin Jin*, Lianbo Guo*, YongFeng Lu, and Xiaoyan Zeng. Discrimination of nasopharyngeal carcinoma serum using laser-induced breakdown spectroscopy combined with an extreme learning machine and random forest method. Journal of Analytical Atomic Spectrometry. 2018. 33, 2083-2088.

25. Yibiao Zou#, Honglin Jin#, Fei Sun, Xiaomeng Dai, Zushun Xu, Sheng-li Yang, Guangfu Liao. Design and Synthesis of Lead Sulfide-Based Nanotheranostic Agent for Computer Tomography/Magnetic Resonance Dual-Mode Bioimaging Guided Photothermal Therapy. ACS Appl. Nano Mater. 2018. 1 (5), 2294–2305.

26. Honglin Jin#, Guifang Zhao#, Jianli Hu#, Quanguang Ren, Kui Yang, Chao Wan, Ai Huang, Pindong Li, Jue-Ping Feng, Jing Chen*, and Zhenwei Zou*. Melittin-Containing Hybrid Peptide Hydrogels for Enhanced Photothermal Therapy of Glioblastoma. ACS Applied Materials & Interfaces, 2017. 9(31): 25755-25766.

27. Honglin Jin, Yuan Qian, Yanfeng Dai, Sha Qiao, Yuan Qian, Chuan Huang, Jing Chen*, Zhihong Zhang*. Magnetic Enrichment of Dendritic Cell Vaccine in Lymph Node with Fluorescent-Magnetic Nanoparticles Enhanced Cancer Immunotherapy. Theranostics, 2016. 6(11): 2000-2014.

28. Yuan Qian#, Honglin Jin#, Sha Qiao, Yanfeng Dai, Chuan Huang, Lisen Lu, Qingming Luo*, Zhihong Zhang*. Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy. Biomaterials. 2016. 98: 171-83.

29. Ying Zheng#, Yanyan Liu#, Honglin Jin#, Shaotao Pan, Yuan Qian, Chuan Huang, Yixin Zeng, Qingming Luo, Musheng Zeng*, Zhihong Zhang*. Scavenger Receptor B1 is a Potential Biomarker of Human Nasopharyngeal Carcinoma and Its Growth is Inhibited by HDL-mimetic Nanoparticles. Theranostics, 2013. 3(7): 477-486.

30. Honglin Jin, Jonathan F Lovell, Juan Chen, Qiaoya Lin, Lili Ding, Kenneth K. Ng, Muthiah Manoharan, Zhihong Zhang*, Gang Zheng*. Mechanistic insights into LDL nanoparticle-mediated siRNA delivery. Bioconjugate Chemistry. 2012. 23(1): 33-41.

31. Haiming Luo#, Jiyun Shi#, Honglin Jin#, Di Fan, Lisen Lu, Fan Wang*, Zhihong Zhang*. An 125I-labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo. Biomaterials. 2012. 33(19): 4843-4850.

32. Mi Yang#, Honglin Jin#, Juan Chen, Lili Ding, Kenneth K. Ng, Qiaoya Lin, Jonathan F. Lovell, Zhihong Zhang, Gang Zheng. Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticle. Small. 2011. 7(5):568-573.

33. Honglin Jin, Juan Chen, Jonathan F, Lovell, Zhihong Zhang*, Gang Zheng*. Synthesis and development of Lipoprotein-based nanocarriers for light-activated theranostic. Israel Journal of Chemistry. 2012. 52(8-9): 715-727.

34. Xiangyong Li, Zhiyong Cheng, Honglin Jin*. Dynamics of Ras complexes observed in living Cells. Sensors, 2012. 12(7): 9411-9422.

35. Honglin Jin, Jonathan F. Lovell, Juan Chen, Kenneth K. Ng, Weiguo Cao, Lili Ding, Zhihong Zhang, Gang Zheng. Cytosolic delivery of LDL nanoparticle cargo using photochemical internalization. Photochemical & Photobiological Sciences. 2011. 10(5), 810-816. (Cover paper)

36. Honglin Jin, Jonathan F. Lovell, Juan Chen, Kenneth K. Ng, Weiguo Cao, Lili Ding, Zhihong Zhang, Gang Zheng. Investigating the specific uptake of EGF-conjugated nanoparticles in lung cancer cells using fluorescence imaging. Cancer nanotechnology, 2010. 1(1): 71-78.



基金项目:

1. 国家自然科学基金面上项目、822728512023/01-2026/12 、主持。

2. 国家自然科学优秀青年基金、82022040、2021/01-2023/12、主持。

3. 华中农业大学生物医学与健康学院创新团队、2022/06-2024/04、主持。

4. 华中农业大学高层次人才启动经费2021/04-2026/04、主持。

5. 湖北省重点研发计划第二批(国际合作领域)、2020BHB021、主持。

6. 国家自然科学基金面上项目、81874233、2019/01-2022/12、主持。

7. 国家自然科学基金青年项目、81503026、2016/01-2018/12、主持。

8. 湖北省自然科学基金面上项目、2019CFB465、2019/01-2020/12、主持。

9. 吴阶平医学基金会专项基金、320.6750.18385、2018/06-2021/05、主持。

10. 2017年华中科技大学“学术新人”、人才启动经费、主持。

11. 武汉协和医院院内基金、2016.03-2018.03、主持。

12. 华中科技大学青年教师基金、2015QN1、2015/01-2016/12、主持。

13. 生物靶向治疗研究湖北省重点实验室开放基金、2015-2017、主持。

14. 中国博士后科学基金特别资助、2013T60721、2013/06-2014/06、主持。

15. 中国博士后科学基金面上资助、2012M521430、2012/06-2014/04、主持。


授权专利:

1. 一种抗肿瘤疫苗复合物及其制剂、制法及应用:金红林,杨坤禹,万超,孙亚洁,张玲玲。专利号ZL201910031298.5

2. 一种促进树突细胞摄取抗原肽的多肽、促进树突细胞摄取抗原肽的纳米颗粒及其应用:骆清铭、张智红、金红林、钱源。专利号ZL201410166872.5

3. 一种同时实现促进树突细胞迁移至淋巴结和多模式成像的方法:张智红、金红林、张宇、戴艳锋。专利号ZL201510788151.2

4. 一种可自组装成水凝胶的肿瘤杀伤性多肽及其应用:邹枕玮,金红林,陈静,伍钢,杨坤禹,胡建莉,彭纲,冯觉平,李品东,赵桂芳。专利号ZL201611105009.4


学术兼职:

担任亚太医学生物免疫学会肿瘤学分会首届委员会委员,湖北省医学生物免疫学学会老年病专委会副主任委员,湖北省医学生物免疫学学会转化医学专委会常务委员,以及湖北省临床肿瘤学会第一届肿瘤微环境专家委员会常务委员。基金委人才项目函评专家和湖北省重点项目评审专家,Journal of NanobiotechnologyBioengineering客座编辑,Chinese Chemical Letters (CCL) Frontiers in Bioengineering and BiotechnologyBioengineering等期刊编委。Nano todayAdvanced Functional MaterialsACS nanoBiomaterialsTheranosticsCancer CommunicationsChinese Chemical LettersFrontiers in OncologyBioconjugate ChemistryFrontiers in Bioengineering and BiotechnologyAsian Journal of Pharmaceutical Sciences30余种期刊审稿人。


主讲课程:

药理学(本科)


联系方式(邮箱):jin@mail.hzau.edu.cn